Seraseal

Primary Hemostatic Agent

SeraSeal™ is an innovative primary haemostatic agent designed to stop bleeding on contact and within seconds for arterial haemorrhages. It is comprised of agar and bovine factor proteins IIa VIIa and IXa and Xa and acts as a catalyst in the clot formation process. This single-component system can tackle any bleeding situation with the potential to save many lives. When seconds count, SeraSeal™ can make the difference between life and death.

The first stage of trauma leads to haemorrhage and inflammation. Haemorrhages lead to shock and resuscitation. And finally, all adverse events- haemorrhage; inflammation; shock; and resuscitation on their own all lead to coagulopathy.

SERASEAL

How SeraSeal™ Works?

There are two distinct pathways for fibrin clot formation – the extrinsic and intrinsic pathways. The vitamin K factors in SeraSeal™ support both clotting pathways to form a fibrin clot in seconds instead of minutes. The fibrin clot adheres to the initial agar barrier reinforcing the physical sealant- “The SeraSeal™ clotting cascade”. The effect on the coagulation cascade system is on blood outside the injured blood vessel and not on the intravascular system.

The intrinsic pathway & the extrinsic pathway, where both the extrinsic and intrinsic pathways share the common pathway to form a fibrin clot, SeraSeal™ catalyzes these specific factors: factors IIa, VIIa, IXa, and Xa. Factor VIa is activated by releasing thromboplastin from the blood vessels, not from SeraSeal™, and before SeraSeal™ is applied to the wound. It is SeraSeal™’s ability to bridge any point in the normal coagulation cascade system that is inhibited by anticoagulation medication such as heparin or warfarin or a factor deficiency.